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The respiratory depression will involve a reduction during the responsiveness from the brain stem respiratory facilities to equally improves in carbon dioxide stress and to electrical stimulation.

Elevated tension inside your head (improved intracranial strain). Stay away from using Promethazine Hydrochloride and Codeine Phosphate Oral Remedy For those who have a head injury or have already been explained to that you've got modifications within the tissue within your brain (Mind lesions) or increased force inside your head.

Promethazine is perfectly absorbed through the gastrointestinal tract. Medical consequences are evident inside of 20 minutes just after oral administration and customarily previous four to six hours, Even though They might persist provided that 12 hours.

The phosphate salt of codeine takes place as white, needle-shaped crystals or white crystalline powder. Codeine phosphate is freely soluble in h2o and a bit soluble in alcohol. The molecular fat is 406.37. Its molecular system is C18H21NO3•H3PO4 • ½ H2O, and it's got the next chemical construction.

Get in touch with community condition Experienced licensing board or state managed substances authority for info on how to prevent and detect abuse or diversion of the merchandise.

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Guarantee accuracy when prescribing, dispensing, and administering promethazine HCl and codeine phosphate oral solution. Dosing problems can result in accidental overdose and Dying.

Withdrawal symptoms can happen in breastfed infants when maternal administration of an opioid is stopped, or when breastfeeding is stopped.

one)]. Instruct clients not to share promethazine HCl and codeine phosphate oral Answer with others and also to take techniques to protect promethazine HCl and codeine phosphate oral Alternative from theft or misuse.

In animal reproduction experiments, codeine administered via the oral route to pregnant rats in the period of organogenesis increased resorptions and lessened fetal weights at a dose about twenty five occasions the utmost proposed human dose (MRHD) while in the existence of maternal toxicity (see Data).

Inform individuals that a residence teaspoon just isn't an precise measuring unit and such use may lead to overdosage and severe adverse reactions [see Overdosage (ten)]. For prescriptions in which a measuring device is not delivered, a pharmacist can provide an proper calibrated measuring product and can provide Guidance for measuring the right dose.

Usage of cytochrome P450 3A4 inducers, 3A4 inhibitors, or 2D6 inhibitors with promethazine HCl and codeine phosphate oral Answer necessitates cautious consideration read more of the results within the mother or father drug, codeine, and the Lively metabolite, morphine.

Food stuff and Drug Administration. Akorn issues voluntary nationwide remember of varied human and animal drug merchandise inside of expiry resulting from enterprise shutdown.

Postmarketing cases of respiratory despair, which include fatalities have already been documented with use of promethazine in pediatric clients.